LymphedemaV1, Main, Exploration, bibRecord, 002404

The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation.

Identifieur interne : 002404 ( Main/Exploration ); précédent : 002403; suivant : 002405

The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation.

Auteurs : Alexandra M. Ochsenbein [Suisse] ; Sinem Karaman ; Giorgia Jurisic ; Michael Detmar

Source :

Advances in anatomy, embryology, and cell biology [ 0301-5556 ] ; 2014.

RBID : pubmed:24276892

Descripteurs français

KwdFr :
- Animaux, Humains, Lymphangiogenèse, Neuropiline 1 (métabolisme), Néovascularisation physiologique, Sémaphorine-3A (métabolisme), Transduction du signal, Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (métabolisme).
MESH :
- embryologie : Vaisseaux lymphatiques.
- métabolisme : Neuropiline 1, Sémaphorine-3A, Vaisseaux lymphatiques.
- Animaux, Humains, Lymphangiogenèse, Néovascularisation physiologique, Transduction du signal.

English descriptors

KwdEn :
- Animals, Humans, Lymphangiogenesis, Lymphatic Vessels (embryology), Lymphatic Vessels (metabolism), Neovascularization, Physiologic, Neuropilin-1 (metabolism), Semaphorin-3A (metabolism), Signal Transduction.
MESH :
- chemical , metabolism : Neuropilin-1, Semaphorin-3A.
- embryology : Lymphatic Vessels.
- metabolism : Lymphatic Vessels.
- Animals, Humans, Lymphangiogenesis, Neovascularization, Physiologic, Signal Transduction.

Abstract

During development, the lymphatic and the blood vascular system form highly branched networks that show extensive architectural similarities with the peripheral nervous system. Increasing evidence suggests that the vascular and the nervous systems share signaling pathways to overcome common challenges such as guidance of growth and patterning. Semaphorins, a large group of proteins originally identified as axon guidance molecules with repelling function, and their receptors, neuropilins and plexins, have recently also been implicated in vascular development. Here, we summarize the role of semaphorins and their receptors in angiogenesis and lymphangiogenesis, with an emphasis on neuropilin-1/semaphorin 3A interactions in lymphatic vessel maturation and valve formation. Understanding the basic principles of lymphatic vessel development and maturation might facilitate the development of therapies for the treatment of human diseases associated with lymphedema.

DOI: 10.1007/978-3-7091-1646-3_11
PubMed: 24276892

Affiliations:

Suisse

Le document en format XML

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<term>Néovascularisation physiologique</term>
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<term>Vaisseaux lymphatiques (métabolisme)</term>
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<term>Lymphangiogenèse</term>
<term>Néovascularisation physiologique</term>
<term>Transduction du signal</term>
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<front><div type="abstract" xml:lang="en">During development, the lymphatic and the blood vascular system form highly branched networks that show extensive architectural similarities with the peripheral nervous system. Increasing evidence suggests that the vascular and the nervous systems share signaling pathways to overcome common challenges such as guidance of growth and patterning. Semaphorins, a large group of proteins originally identified as axon guidance molecules with repelling function, and their receptors, neuropilins and plexins, have recently also been implicated in vascular development. Here, we summarize the role of semaphorins and their receptors in angiogenesis and lymphangiogenesis, with an emphasis on neuropilin-1/semaphorin 3A interactions in lymphatic vessel maturation and valve formation. Understanding the basic principles of lymphatic vessel development and maturation might facilitate the development of therapies for the treatment of human diseases associated with lymphedema.</div>
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Serveur d'exploration sur le lymphœdème

The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation.

The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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